Aragorn said:
Thanks Galaxia, interesting information. Did the lecturer mention if NAC was effective in removing mercury from the brain too?
Hi Aragorn, She said that she had autistic patients and that they improve neurologically, but she doesn't said it explicitly. But I think the trick is to take Alfa lipoic acid that do cross the blood-brain barrier and can transport the mercury to where NAC or other chelant can take it. Selenium also helps in that way. In fact as already psyche has explained there is a protocol for DMSA that could be adapted to this.
There is another approach to the problem that was discused and is based in the use of dietary fiber for maintenance.
From
J.P.K. Rooney / Toxicology 234 (2007) 145–156
Dietary fibre
Information on the influence of dietary fibre on mercury
toxicity is lacking. However, in vitro studies have
shown that wheat bran can effectively bind mercury and
other heavy metals (Ou et al., 1999). In mice exposed
to methylmercury, a 30% bran diet was seen to increase
the rate of elimination of mercury from the body and to
reduce the level of mercury present in the brain (Rowland
et al., 1986). It has also been reported that apple pectin
led to a reduced period of intoxication in children with
increased urinary excretion of mercury (Sobolev et al.,
1999).
This author proposes a potential mechanism of
action by which increased dietary fibre may increase
the elimination of methylmercury.
Methylmercury is
known to undergo extensive entero-hepatic recirculation
(Clarkson, 2002). As fibre has been shownin vitro to bind
mercury and as fibre is non-absorbable, it is proposed that
fibre in the diet interrupts the entero-hepatic recirculation
by binding the mercury and undergoing excretion, thus
leading to an increased rate of elimination of mercury.
Furthermore, Gregus et al. (1992)
have suggested
that alpha-lipoic acid leads to increased biliary excretion
of inorganic mercury in the form of DHLA–Hg2+
complexes. As these complexes are organic-like mercury
species, it isworth considering that these complexes may
be reabsorbed by the intestine with high efficiency similar
to organic mercury species such as methylmercury. If
this were the case, and if fibre can bind these complexes,
an increased fibre intake may potentially lead to reduced
reabsorption of these complexes, which would lead to
improved treatment efficacy and reduced side-effects.