DMSA for heavy metal detox - how long available?

Infiniteness said:
I will do more research in to alternative metal detoxs or mercury detoxs, one that I am considering is Algas.

There is an alginate made out of seaweed. That and modified citrus pectin. FWIW:

http://www.cassiopaea.org/forum/index.php?topic=10573.msg146213#msg146213

I've read about homeopathic remedies, but it seems quite tricky.
 
aleana said:
I decided to visit a local compounding pharmacy. One of the pharmacists recommended "ChelaClear" by NuMedica. It contains DMSA, EDTA, Cilantro, Chlorella, garlic extract, NAC and ALA. So it sounds fairly robust. The pharmacist also recommended taking some minerals (a product by Standard Process) to help replenish in between courses of the chelation - I was not sure if this was the correct thing to use, so have not bought them yet.

This would be great if it is sufficient, as it's cheap, compared to buying all those sup's in isolated cans.

30 $ for 120 tablets

_http://www.healthdesigns.com/numedica-chelaclear-120-capsules.html
DMSA 100 mg
EDTA (as calcium EDTA) 300 mg
Cilantro 300 mg
Chlorella 300 mg
Allicin (as organic garlic extract) 6000 mcg
N-Acetyl Cysteine 200 mg
Alpha Lipoic Acid 200 mg

Other Ingredients

HPMC (vegetable capsule), vegetable stearate, silicon dioxide.
Contains No: Wheat, gluten, corn protein, yeast, soy, dairy products, artificial colors, sweeteners or preservatives.

any red flags here?
 
_http://www.healthdesigns.com/numedica-chelaclear-120-capsules.html
Quote
DMSA 100 mg
EDTA (as calcium EDTA) 300 mg
Cilantro 300 mg
Chlorella 300 mg
Allicin (as organic garlic extract) 6000 mcg
N-Acetyl Cysteine 200 mg
Alpha Lipoic Acid 200 mg

Other Ingredients

HPMC (vegetable capsule), vegetable stearate, silicon dioxide.
Contains No: Wheat, gluten, corn protein, yeast, soy, dairy products, artificial colors, sweeteners or preservatives.

any red flags here?

I would love to know the answer to this as well. I have been holding this product aside for awhile since right after I bought it, I read in Stanley Baker's Detoxification and Healing the following comment about DMSA (page 112-113). He goes into a long description of the schedule for using DMSA and then says this.....

"In the past year I have started using a skin cream containing a form of vitamin B1 with another cream containing reduced glutathione. This combination may provide a safer means for detoxification of mercury"

Since I am doing this without a doctor at the moment, this caused me some concern, so am still eating cilantro/chlorella as often as possible until i get the courage to try the DMSA. I wonder what he meant by SAFER, i.e. what is this stuff going to DO to me??? :huh:
aleana
 
The formula looks ok, although you need to take DMSA only for 3 days of the cycle. NAC and ALA must be taken on a regular basis.

The thing of oral heavy metal chelators is that they may upset the digestive system, and also your digestive system must be ideally free of yeast overgrowth before you try this route, as some of the supplements which chelate heavy metals can cause an exacerbation of candida overgrowth.
 
Psyche said:
Infiniteness said:
I will do more research in to alternative metal detoxs or mercury detoxs, one that I am considering is Algas.

There is an alginate made out of seaweed. That and modified citrus pectin. FWIW:

http://www.cassiopaea.org/forum/index.php?topic=10573.msg146213#msg146213

I've read about homeopathic remedies, but it seems quite tricky.

I see, a very good read! Also shows us how bad the toxic problem is and a good reminder do it! I also believe that the only way to keep toxins and bay is to keep detoxifying, because are environment is filled with so many, sadly.
 
This question might be very dumb, but "...take on empty stomach" , does that mean no liquids? (tea/water) Just started my DMSA and took the first 2 x 100mg.
 
GRiM said:
This question might be very dumb, but "...take on empty stomach" , does that mean no liquids? (tea/water) Just started my DMSA and took the first 2 x 100mg.

Take it with water and then wait around 30' before you eat. Or if you ate, wait for a couple of hours before you take DMSA.
 
Today I attended a symposium in my college related to mercury poisoning, her determination, some studies in people in mining regions and finally came a Doctor in charge of the toxicology division of a public hospital. She is one of the few people who applied treatments of this type in my country and she gave a very interesting talk and really went out very happy with what I learned there. :D Let me tell you the "novelty." Well, she was explaining the details of all the chelators that are commonly used and we already know. She also spoke about DMSA. But what surprised me was that she said "We do not use any of those because there are no resources in the hospital and they are very expensive"
The "surprise" was that she uses NAC since 10 years ago, because it is produced here. She uses high doses. She described her statistics with their patients. In all patients the level of mercury was reduced to a minimum and she explained that unlike other chelating she has not observed nephrotoxicity or liver toxicity. One of the listeners refutes her that there are publications where it is observed nephrotoxicity but she said "that's not what we have seen."

She has intentions to publish their results but she need work on a larger population.

She struck me as a person who has no vested interests and in fact works in very difficult conditions.

In short the treatment is as follows: (a modification of parecetamol toxicity treatment)

It can be oral or parental (in severe cases with hospital stay)

Consists of cycles of seven days with breaks to replenish lost minerals

First day: Starting dose 140 mg / Kg
Days 2-6: 70 mg / kg / 6 hours
1-week rest

Each cycle reduces the amount of mercury in a half (tested with analysis).


Another thing I learned is that the blood mercury analysis gives information only if there has been contact with mercury up to 3 days earlier. To know about the mercury accumulated you need to take the urine sample.

This seems a good alternative because DMSA is too expensive and there is no it in my country.
 
Thanks Galaxia, interesting information. Did the lecturer mention if NAC was effective in removing mercury from the brain too?
 
Aragorn said:
Thanks Galaxia, interesting information. Did the lecturer mention if NAC was effective in removing mercury from the brain too?

Hi Aragorn, She said that she had autistic patients and that they improve neurologically, but she doesn't said it explicitly. But I think the trick is to take Alfa lipoic acid that do cross the blood-brain barrier and can transport the mercury to where NAC or other chelant can take it. Selenium also helps in that way. In fact as already psyche has explained there is a protocol for DMSA that could be adapted to this.

There is another approach to the problem that was discused and is based in the use of dietary fiber for maintenance.

From J.P.K. Rooney / Toxicology 234 (2007) 145–156

Dietary fibre

Information on the influence of dietary fibre on mercury
toxicity is lacking. However, in vitro studies have
shown that wheat bran can effectively bind mercury and
other heavy metals (Ou et al., 1999). In mice exposed
to methylmercury, a 30% bran diet was seen to increase
the rate of elimination of mercury from the body and to
reduce the level of mercury present in the brain (Rowland
et al., 1986). It has also been reported that apple pectin
led to a reduced period of intoxication in children with
increased urinary excretion of mercury (Sobolev et al.,
1999).

This author proposes a potential mechanism of
action by which increased dietary fibre may increase
the elimination of methylmercury. Methylmercury is
known to undergo extensive entero-hepatic recirculation
(Clarkson, 2002). As fibre has been shownin vitro to bind
mercury and as fibre is non-absorbable, it is proposed that
fibre in the diet interrupts the entero-hepatic recirculation
by binding the mercury and undergoing excretion, thus
leading to an increased rate of elimination of mercury
.
Furthermore, Gregus et al. (1992) have suggested
that alpha-lipoic acid leads to increased biliary excretion
of inorganic mercury in the form of DHLA–Hg2+

complexes. As these complexes are organic-like mercury
species, it isworth considering that these complexes may
be reabsorbed by the intestine with high efficiency similar
to organic mercury species such as methylmercury. If
this were the case, and if fibre can bind these complexes,
an increased fibre intake may potentially lead to reduced
reabsorption of these complexes, which would lead to
improved treatment efficacy and reduced side-effects.
 
Thank you for update Galaxia2002! :thup:

It is very nice to see that some people have found ways to chelate mercury with inexpensive treatments.

High doses of NAC are used as an antidote for acetaminophen poisoning as well and NAC has also been used for kidney protection when people are going to have diagnostic tests which require the injection of toxic contrasts into their bodies (like CT scans or MRI with radio-contrasts).

The urine levels of mercury are a useful guide, but still not a certain indicator. Here is something about it:

http://www.cassiopaea.org/forum/index.php?topic=16812.msg147204#msg147204
http://www.cassiopaea.org/forum/index.php?topic=16812.msg147217#msg147217
 
Psyche said:
Gandalf said:
I have done 2 cycles and so far I have no symptoms. Geez, I am wondering if it is normal :huh:

Wait for another couple of cycles to see how it goes, sometimes it doesn't come out initially. Here are some of the observations on this:

http://www.cassiopaea.org/forum/index.php?topic=16812.msg147204#msg147204
http://www.cassiopaea.org/forum/index.php?topic=16812.msg147217#msg147217

4 cycles are done now and so far I still have no symptoms.
 
Psyche said:
Baker's protocol is the same one for mercury detox in autistic children:

DMSA
Vitamin C
Alpha lipoic acid
Zinc
Selenium
Vitamin B6
Vitamin E
Melatonin
Taurine
Reduced glutathione (Even if it doesn't get absorbed, apparently it helps to heal the gut, but we use NAC)

I'm starting dmsa tomorrow, I bought some reduced glutathione but now seeing your post Psyche should i drop it and take NAC instead or since I got both maybe use them together.
 
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