Thanks for this interesting session and speedy transcription!
Question is - how much doxycyclin is LOW DOSE?
Normal dose for infection and as malaria prophylaxis is generally 100mg/ day (may be more in some infections).
However in the treatment of the skin inflammation rosacea, doses as low as 40mg/d are used.
Found this interesting article, in which it says, that the effect of doxycyclin in rosacea is not due to its antibiotic property, but to its anti-inflammatory property:
Source
I thought that this is pretty interesting ...
So my take on this is that a LOW DOSE would be 40mg/ days divided in 2 doses ... or maybe even lower?
FWIW
Laura said:stella maris said:Doxycycline is a tetracycline class antibiotic and kills various bacteria but not virus.One have to be careful in a prolonged use, it contraindicate contraception and stains the teeth and also is not good to take calcium, iron or sodium bicarbonate as diminishes the works of this antibiotic...this whole thing made me think..this viruses are living in bacteria so then we have a secondary infection, so if we kill this particular bugs virus can no longer exist in the body?does not make a sense...did any body at any time asked C'cs about AIDS? I have not found anything jet on the site unless I missed it Otherwise Thank You! very entertaining
Have you done any research on LOW DOSE doxycycline? I think not. None of the above applies to this protocol.
Question is - how much doxycyclin is LOW DOSE?
Normal dose for infection and as malaria prophylaxis is generally 100mg/ day (may be more in some infections).
However in the treatment of the skin inflammation rosacea, doses as low as 40mg/d are used.
Found this interesting article, in which it says, that the effect of doxycyclin in rosacea is not due to its antibiotic property, but to its anti-inflammatory property:
The use of oral antibiotics to treat rosacea dates to at least the1960s.39 It has been proposed that tetracyclines were first used in rosacea on the assumption that an infectious etiology caused the disease. However, an article published in 1966 acknowledged that the mechanism of action of tetracycline in rosacea was unknown but was not thought to be associated with antiinfective properties.40 Over the ensuing four decades, doxycycline and other tetracyclines have been shown to produce a number of anti-inflammatory effects that may contribute to their beneficial effects in patients with rosacea. The tetracyclines, generally classified as antibiotics, have a range of therapeutic effects that are independent of antimicrobial mechanisms. In fact, tetracyclines have current or theoretical applications in periodontitis, arthritis, osteoporosis, and cancer.41-43
Doxycycline and other tetracyclines have been shown to reduce the production of interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α)44 and may reduce neutrophil chemotaxis.45 Tetracyclines also reduce the activity of phospholipase A2, a family of inflammatory enzymes.46 Doxycycline reduces the generation of neutrophil-derived toxic reactive oxygen species, including superoxide anion, hydrogen peroxide, and the hydroxyl ion.47 In vitro studies show that doxycycline can reduce the production of nitric oxide by epithelial cells at concentrations as low as 3 µg/ml.48 Doxycycline has also been shown to reduce angiogenesis in animal models.
Appreciation of the anti-inflammatory effects of tetracyclines may be attributed to research with chemically-modified tetracycline (CMT) analogues. There are at least 10 CMTs, modified so that the dimethylamino group from carbon- 4 position (the side-chain required for antimicrobial activity) is removed. These analogues provide no antimicrobial effect, but they inhibit synthesis of collagenase and other matrix metalloproteinases and down regulate cytokines in animal models.42-44 The anti-inflammatory effects of the tetracyclines are thought to produce their efficacy in rosacea therapy.51
Source
I thought that this is pretty interesting ...
So my take on this is that a LOW DOSE would be 40mg/ days divided in 2 doses ... or maybe even lower?
FWIW