Rife-like solutions can be promising, especially for bacteria. Not sure it would work on mycoplasma because of their lack a cell wall. From an out of the head point of view, the use of square waveforms in not necessary because it would involve harmonics that can have side effects on other intra cellular processes. Pure waveforms can be experimented with, for short periods, provided that one has a means to verify the effects of a given frequency on an in vitro sample. For example, you take a tissue sample, you identify the target (bacteria, or other), apply a signal (using a tunable frequency generator) and once you have the good frequency, you apply it, retake a sample, etc. I haven't seen such a protocol being applied so far, which tend to make the procedure a little questionable, although it doesn't seem to be complicated if one has a good medical microscope. OSIT