A: Weather will play a more prominent role next.
A: Nature will also intervene. Watch for it!
A: Be calm! Things will change! Love and Goodbye.
I read that the virus was also found in sperm in acute infected people. The question then would be whether its function could also bring about a kind of birth control through sperm changes.
Some of our ancient viruses may be protecting us from disease; others may be raising our risks for cancer, among other conditions. “It’s not an either-or — are these things good or bad? It’s a lot more complicated than that,” Dr. Katzourakis said in an interview. “We’re barely at the beginning of this research.”
Most of our viral DNA comes from one group in particular: retroviruses, a group that includes HIV.
A retrovirus invades a host cell and inserts its genes into that cell’s DNA. These viral genes co-opt the cell’s machinery, using it to make new viruses that escape to infect more cells.
If a retrovirus happens to infect an egg or sperm, its DNA can potentially be passed to the next generation and the generation after that. Once retroviruses become inherited stowaways, scientists refer to them as endogenous retroviruses.
At first, endogenous retroviruses coax cells to make more retroviruses that can infect other cells. But over the generations, the viral DNA mutates, and endogenous retroviruses eventually lose the ability to infect new cells.
Even after being hobbled, these endogenous retroviruses can still sometimes make their proteins. And they can also reproduce, after a fashion. They can force cells to make copies of their DNA, which are inserted back in the cell’s own genome.
So it's the normal mother strain that has been genetically modified. Unpacking the genome means that special cells e.g. Lung tissue attacked?
How is this virus potentially unlocking beneficial codons? And here's where I would like to bring some molecular biology concepts of the virus. The vocabulary background is technical, but all the 101 information is available for everybody. I posted a video with the 101 molecular biology of the coronavirus here as well: Coronavirus Pandemic: Apocalypse Now! Or exaggerated scare story?
According to molecular biology concepts, the virus has a mechanism to readthrough its genetic code (the ability to transcribe a genetic sequence beyond its normal termination sequence) via a frame shifting event that is governed by two properties of the genomic RNA of the virus.
First, a slippery sequence that facilitates a "slip out of the frame" when the ribosome reads the genomic sequence and which is increased in coronaviruses because downstream of the "slippery sequence" is what is called an "RNA pseudoknot structure" (second property) which is a highly stable RNA structure that causes the ribosome when it encounters it to pause over the slippery sequence increasing the chances that it will slip back out of frame. If it slips back one nucleotide out of frame, stop codons are no longer read as a stop codon and the ribosome can continue to translate whatever is next. I would think that this is one way to unlock suppressed codons depending on how the virus interacts with its hosts, or vice versa, how the host interacts with the new virus.
The other interesting thing about coronaviruses is that they have subgenomic RNAs which are like a nested set of codes, which allows the coronavirus to have its structural proteins and accessory proteins transcribed. Subgenomic RNAs transcription is discontinuous and is facilitated by shared transcription regulatory sequences which basically allows for jumps across the genome, transcribing genes here and there. Potentially, this could be another mechanism the virus can activate suppressed codons.
A: Oleakmaea of Cassiopaea. And you are most welcome!!
Q: (L) Are you saying, "most welcome" because I was thinking just before we started how thankful I was that we have the C's to talk to, and that they give us all the good advice they give? And because they warn us in advance of things that are gonna happen and keep us at least in a state of mind where we can function amidst all this madness? Is that what you were responding to?
A: Yes
A: Be calm! Things will change! Love and Goodbye.