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Addiction.
I
have made the statement that we are made addicts inside our own
skins.
And,
I am fairly certain that most people reading that remark are quite
certain that they are not! Especially if they are careful of their
diet and habits of mental and physical hygiene.
But,
I say again: we are made addicts inside our own skins.
And,
what's more, we are addicted to our emotions.
Curiously,
the ones who resist that idea most strenuously are very much like
an alcoholic who vigorously and vehemently declares that he is
NOT an alcoholic.
Alcohol.
Alcohol
is everywhere. Tens of millions of human beings experience the
consequences of alcohol addiction, from decreased job performance
to liver damage to spouse and child abuse, to total breakdown
of social concepts and constraints ending in the proverbial "skidrow
bum" looking every day for his MD 20-20 - or even a can of
Sterno.
And
that is just alcohol. We aren't even going to list the statistics
for other drugs as it would be tedious and pointless. You have
the idea.
Alcohol
and other drugs have the ability to do what they do in our systems
because they act because they are "fixed;" they are
synthetic ligands; they bind to our receptors and, in various
ways, produce their effects. It is the nature of these specific
effects that we now want to examine.
When
an ovulating female boar is exposed to a pheromone from a male
boar's saliva, the scent travels along the olfactory nerve directly
into the amygdala, stimulating the release of neurotransmitters,
the result of which is that she becomes immediately and completely
paralyzed in a spread-legged mating posture! Naturally, this fact
has led to the marketing of a number of pheromone based men's
colognes designed to produce the same effect in the human female!
(Nice try, guys!)
If
you give rats in a cage access to both food and cocaine, the rats
will consume the cocaine and ignore the food. And they will end
up starving themselves to death with a limitless supply of food
available. And, of course, that makes us think of the alcoholic
who has gin for breakfast, bourbon for lunch, and brandy for dinner
- ending up in the hospital with a severe case of malnutrition.
Caffeine
is the most frequently used drug of all. In his Coffee Cantata
of 1732, J.S. Bach wrote:
Ah!
How sweet coffee tastes! Lovelier than a thousand kisses, sweeter
far than muscatel wine!
A couple of centuries later, Isak Dinesen wrote:
Coffee...
is to the body what the word of the Lord is to the soul.
Caffeine
has a strong effect on nearly every animal species. Rats being
taught to navigate through mazes learn their lessons faster after
being given coffee. Not only that, but they remember better. Competitive
cyclists have discovered that they can pedal 20% longer if they
drink caffeine an hour before racing. Some of them even go to
the extreme of using caffeine suppositories before racing - sort
of a "time release" kick in the behind!
Following
ingestion of caffeine, even sperm get a "kick." They
swim faster and wiggle more vigorously increasing their ability
to "hit the spot!"
And,
for most people, caffeine is generally safe. After years of searching
for negative side effects, there is no real evidence that moderate
consumption of caffeine does us any harm. If it gives you the
jitters, just cut back. It's one of the perks of 3d density experience,
in my humble opinion!
What
we want to know here is, how does caffeine work?
As
our neurons process information, they produce cellular waste including
a buildup of molecules of adenosine. Adenosine is a ligand that
binds with the adenosine receptor sending a message deep into
the cell that it is time to sleep. As the production of adenosine
continues throughout the day, as a byproduct of cerebral activity,
more and more adenosine is produced, binding with more and more
receptors, sending more and more sleep messages into more cells.
And little by little our brain cells become more and more sluggish
until we just simply must go to sleep. We literally can't remain
conscious. We yawn; our eyes water and try to close and we just
want to curl up and let the lights go out.
So,
we have a cup of espresso. The caffeine molecule just happens
to be the right "shape" for the adenosine receptor.
It hops on and binds, thereby blocking the real adenosine which
sends the sleep message. Apparently, caffeine sends a different
message, or at least prevents the sleep message from being sent.
It interrupts the sleep signal.
This
is just a small example of how dramatically chemicals can affect
the brain.
We
have already mentioned the rats who were implanted with electrodes
for self-stimulation who would push the button until they were
exhausted. Well, there were additional experiments done along
this line. It seems that if the electric reward is doled out only
when the rats learn a new trick - such as navigating a maze
- the little critters will go to work like crazy to get the job
done so that they can get their "buzz." As long as the
rewards keep coming, the rats will keep working - even mastering
incredibly complex and seemingly impossible mazes that humans
would find nearly impossible!
But
it's not the learning they love. We already know that, given the
opportunity, they will forget everything - food, mates, friends,
whatever - to push that damn button until they collapse in mindless
ecstasy!
Now,
in the human being, (as in other creatures), the sensation that
is experienced as orgasm is the same release of chemicals that
stimulate the same part of the brain that makes the rats so happy.
Some scientists refer to this in technical jargon as the "do-it-again"
center. [cf. Burnham and Phelan.] When this center is stimulated,
whatever activity is associated with it will be sought again and
again.
We
have, it seems, a lot of "do-it-again" chemicals with
a lot of "do-it-again" receptor sites all over our bodies.
Certain foods in different people act in this way. Some people
feel euphoria when they achieve victory over a rival in some sort
of competition. Aside from the most obvious example of sex, these
are examples of other things that can cause the secretion of these
"do-it-again" chemicals.
By
having such a "pleasure system" in our bodies, we have
a built in reward system by which we can be manipulated to pursue
any number of activities that may or may not be good for us;
mostly based on - you guessed it - early imprinting. And, we are
generally unaware of it; we simply engage in certain behaviors
because it "feels good" and we want to do them "again."
We were rewarded for them as infants and small children, and we
constantly seek that "programmed behavior" in order
to receive the reward. Never mind that our early programming may
have been for behaviors that completely block the true expression
of our "essence," or that they are based on "fairy
tales" or unrealistic perceptions of life.
Now,
drugs "short circuit" these centers. The ways that drugs
work are interesting, but in our context here, we just want to
look at them as a sort of path to understanding the body's own
chemicals..
When
we take certain drugs, our brain acts as if the "natural"
neurotransmitter were flooding the system. The brain thinks we
have done something really great such as finding food or warmth
while, in reality, we may be hunkered down in a flophouse with
a hypodermic of heroin in our arm. Our pleasure centers know only
that they are bathed in chemical bliss. Never mind that the first
time we tried it, we were disgusted and repelled by the setting,
the process, all the external elements. Once we have received
that reward, we are convinced that this nasty setting, this ignominious
behavior that is clearly damaging to the self, is "okay"
and "desirable" for the reward we are going to get.
Now,
let's take a look at this in a practical way. Psychologist Barbara
De Angelis writes:
Falling
in love is a magical and powerful experience. Each kiss, each
conversation, each moment in the beginning seems so right, so
perfect. But soon attraction and infatuation become a "relationship,"
and we are brought down to earth with the challenging realities
of sharing our life with another human being. And as those first
enchanted weeks turn into months, one day we find ourselves asking:
"Is this person right for me?" ...Since my first serious
relationship at seventeen, and, until recently, I fell in love
without giving serious consideration to whether the person was
right for me, let alone whether they loved me enough. Someone
showed up, and if he had something lovable about him, I would
start a relationship. I'd convince myself he was "the one,"
only to find out that we were incompatible and watch the relationship
fail. ...After too many heartbreaks, I was forced to face the
sad truth: In spite of my experience, education, and my intense
desire to be happy, I continually chose partners who were not
right for me. I was falling in love with the wrong people for
the wrong reasons.
Such
situations arise because of the "fairy tales" we are
taught as children; the examples of "lying to ourselves"
about our true feelings that are set because we are told and shown
that rewards only come when we suppress our true feelings and
follow the "rules." Dr. De Angelis continues:
Ask
most people why they fell in love with their partners, past or
present, and you'll probably hear answers like this:
I met Kathy at the gym where I work out. Something about the
way she got so into that aerobics class and gave it so much
energy really appealed to me.
[All
Kathy's boyfriend knows about her is that she has a lot of physical
energy and he is programmed by his particular socio-cultural
system to believe that physical energy is very good and will
be rewarded. Thus, somebody who has a lot of physical energy
is "lovable." He may also have had very positive experiences
with someone in his childhood who had a lot of physical energy,
and who regularly made him feel loved.]
Donna was a bridesmaid at my cousin's wedding. She looked so
beautiful in this pink strapless dress - I knew on the spot
I was going to fall in love with her.
[All
Donna's boyfriend knows about her is that she looked good in
pink chiffon. We might think that the color pink has powerful
associations in his amygdala.]
Jo
Anne and I knew each other since we were kids. Everyone always
said we'd probably get married when we grew up, and I guess
I never even questioned it - it seemed like the right thing
to do.
[Jo
Anne's husband has been so influenced by what his friends and
family think that he doesn't even know why he loves her. We
might think that "obedience to the family" has received
some very positive reinforcement in his life. Conversely, thinking
for himself may have received a great deal of negative reinforcement.]
Alex
and I were assigned to work together on a project in our office.
I think it was watching him problem-solve - he is so creative
- that attracted me to him.
[Alex's
girlfriend is enthralled with his business skills but has no
idea what his emotional skills are. Creativity in solving problems
may have been well rewarded in her home environment as a child.
She may also have been exposed to highly creative "problem
solvers" as male role models, receiving regular rewards
from them. Thus, she associates these skills with love.]
I've
always been a sucker for music, so when I heard Frank play the
guitar at a friend's house, I knew he was the one for me.
[Frank's
partner has fallen under a musical spell - she knows nothing
about him except for the romantic personality she assumes all
guitar players have. And why does she assume this? Because it
is programmed into her amygdala!]
This
sounds terrible, but I always had this fantasy of a tall, dark-haired
man with a mustache. Dennis looked exactly like that, and nothing
else really mattered.
[Dennis's
girlfriend likes the way he looks - she is attracted to a fantasy,
but doesn't know anything about the person underneath. And where
did she get the fantasy? A program.]
None
of these people thought they were making the wrong decision.
They all sincerely believed that they were making intelligent,
sensible choices in their partners. But, the frightening truth
is that many of them will discover in a month, or six months,
or six years that they are in a relationship with the wrong
person.
Most
people put more time and effort into deciding what kind of car
or video player to buy than they do into deciding whom to have
a relationship with.
Love
myths are beliefs many of us have about love and romance that
actually prevent us from making intelligent love choices. ...Consciously
and unconsciously, we base our decisions in relationships on these
Love Myths. An example is: If I love my partner enough, it won't
matter that:
he
drinks
our sex
life isn't great
she criticizes
me all the time
we fight
constantly over how to raise the children
he is
a strict Catholic and I am Jewish
I'm not
really sexually attracted to her
he doesn't
have a job and hasn't worked in two years
she has
a terrible temper and blows up all the time
he constantly
flirts with other women
I don't
get along with her children
he has
a hard time telling me how he feels
his family
doesn't accept me
I want
children and he doesn't
she still
hasn't gotten over her ex-boyfriend
One
way to tell if your relationships are simply "running the
program" is to examine how you "prove" to yourself
that you are really "in love." Do you dwell on the intense
connection of chemistry of the beginning, trying always to recapture
this, and fail to examine the rest of the relationship?
Have
you ever convinced yourself that you love your partner to justify
continuing to have sex with them, even though the fire has long
ago gone out?
Conversely,
have you ever been in a relationship where the only place you
got along together was in bed?
When
we believe the Love Myths, we inevitably become involved with
people we are not really compatible with. We feel constantly empty,
and none of our needs are fulfilled. And, at the same time, even
if we are trying to fulfill their needs, they always seem to know
that it is an effort to get them to fulfill our needs, and the
relationship has nowhere to go but down.
And
then we are faced with the next Love Myth problem: We stay in
the relationship longer than we should and have trouble letting
go of a partner who, in moments of cold clarity, we realize are
NOT right for us. We do this because we are taught to do it. We
see the examples set for us as children; we are rewarded for not
being a "quitter," and are inculcated in the belief
that "a promise is a promise," and keeping promises,
at whatever cost to us, is rewarded, and breaking them will result
in dire consequences. The family pressures of our social and cultural
beliefs come into play strongly here, and we are convinced that
we must always sacrifice our wants and needs for those of others.
We must "suffer" to be "good," and to be "rewarded."
We live our lives like Dicken's Oliver saying: "I want more."
And we want more because we are starved and drained, and manipulated
to suffer so as to be "food" for 4th density STS.
Now,
let's look at a real-life situation that plays out the drama exactly
as the theorists have predicted:
Some
time back I received correspondence from a reader who wrote to
me describing her years of suffering; her dreadful childhood,
her marital unhappiness, suicidal feelings, and on and on. She
described her father as: "a highly intelligent and spectacularly
manipulative individual, endowed with psychic energies and a very
heavy 'presence'," and her mother as "beautiful, clever,
unhappy, terrorized by my father - as was I - and learned to like
alcohol."
She
described her first marriage, children and divorce, increasing
health problems and finally meeting her present husband who "was
the first person I knew who was willing to accept me and my children.
I was not "in love" with him though I found him attractive. I
thought love would come later. ... Later we had two children of
our own."
The
next remark is particularly telling considering the description
of her father as "highly intelligent and spectacularly manipulative
individual, endowed with psychic energies and a very heavy 'presence'..."
She wrote:
My
husband also has strong intuitive and psychic abilities... My
husband and I bickered almost from the start, and it only grew
worse. Not a day has gone by in over 30 years of marriage that
we have not been at each other's throats, or without raised
voices. Our life together has been chaotic, moving constantly,
no coherent thread to my life though it doesn't seem to affect
him much. He loves to travel, and I did too at first. Now I
am numb. Our misadventures along the way would make a saga.
I have always turned them into comedies, but underneath there
is a great waste of a life. My life.
But
notice: even though she describes her husband as "psychic,"
reflecting the programmed imprint of the father, and clearly she
is looking for a father because she was not "in love,"
but she married him because he accepted her and her children,
she does not ascribe to her husband the same "heaviness"
of the father, nor the "spectacular" manipulativeness.
She has made a conscious effort to NOT "marry the father."
And yet... she did. Not only that, she "became her mother."
No, she is not "terrorized" by her husband, not in the
overt way her father did it - but the result is exactly the same.
You could even say that it is a form of unconscious manipulation
through poverty as is clear in the following remark:
And
strangely he once said he wondered if I brought him my "bad
luck," for our life together has been an unending series of
bad choices, bad decisions, financial catastrophes. Even our
friends over the years have shaken their heads in mystification.
Apparently,
this husband is a far better manipulator than her father was -
mainly because he is not even conscious that he is manipulating.
One of the clearest clues to being manipulated is feeling "guilty."
I
am consumed by guilt which has been my overriding emotion
for all the years of our marriage. Guilt over what I can't
imagine. The failure to make another happy? But why can't he
see I am dying by inches? ...I have not accomplished what I
need to in this life, and I never will as things are. ...why
had I always put off my own path and tried to please everybody
else and live up to their own agendas?
So,
even though we read in these words the fact that this woman clearly
has all the answers to her problems right there in her own psyche,
she cannot SEE them. The soul inside her is dying to live. But her
programs are too strong. The "belief in the Love Myths"
is dominating, and the clear and present danger of the predator
is not even suspected.
I
have lost all interest in anything except the natural world
I see on my daily walks. I must have wept gallons of tears in
the past several months. Anything will trigger me off. I look
at a cloud and start weeping. Yet my husband notices nothing.
Nothing at all, save for the fact I am a little ......... undemonstrative.
I long for solitude, for inner freedom, for tranquillity. The
thought of saying this to my husband is terrifying. ...Every
day I fade a little more.
Why
is it "terrifying" to tell her husband what she is feeling?
Remember, she has married someone who is not terrifying, someone
she can fight with and talk back to... not someone like her father
who "terrorized" her mother. Yet, she is no less terrorized!
Two
of my children - who love their father by the way - agree with
my assessment of him as an overbearing human 'steamroller.'
But,
even with the agreement of her children, they are all in agreement,
so it would seem, that this is a "burden to be borne"
because of "love." Nevertheless, it is a certainty that
this "spectacularly manipulative" husband of hers "senses"
that he is losing his grip on her, and the manipulation takes a
new turn: health. You can't abandon a sick man, for sure, or society
and everyone else will punish you and reject you and you definitely
won't get your emotional "fix" by being a "good girl."
Last
fall my husband was diagnosed with Hodgkins' Lymphoma. He almost
died. He was away in the hospital for 3 months and I was here
alone. For the first time in 30+ years I felt lighthearted,
as if a weight were lifted off me. I was totally happy. I knew
I could never tell him so. My mind became sharp again and I
actually gained weight (I had grown gaunt). Now he is back and
ending his chemotherapy. And I have become deeply depressed,
talk myself out of it for several days, then once more think
of death - and hope my body will respond to my wish.
And
here we have the greatest clue of all as to the machinations of
the "feeder lines" of 4th density STS: they must be in
proximity to work. With the absence of the husband, everything changed.
And, of course, it was an "absence" that was not due to
her actions - at least not apparent to her, though it is exactly
as likely that he is suffering inside as much as she is, with less
ability to articulate it. Her proximity to him stimulates the chemicals
of suffering in him that makes him a good meal; and conversely,
his proximity to her stimulates the release of the chemicals that
make her a good meal. It's a two-way street. But, of course, this
period of respite helped her to come to a realization:
I know I must leave him, though it will hurt him terribly. He
has always loved me, and never understood why I am not more
demonstrative. I have tried, but my heart is nowhere.
And,
the problem here is the fact that, just as she is living in a
Love Myth, so is he. Her myth says that he will suffer terribly
if she leaves; and his myth says that he will suffer terribly
if she leaves. Problem is, they are both myths. She ended her
letter with:
If
the C's can shed any light on this issue, or point out
for me what I do not see clearly, it might save my life
- if not in the physical sense, certainly in the greater
sense. ... I leave it up to you.
Well,
as the reader has probably already figured out, it didn't take
the Cassiopaeans or even a rocket scientist to figure this one
out. I did think about one woman who advised me against my own
divorce by telling me: "the devil you know is better than
the devil you don't know." The idea was, that if I divorced,
I might make the same mistake again, and be in an even worse situation.
But, my response to that was that the devil I knew was well enough
known that I didn't need to learn anymore about him to know that
being alone was a better option.
I
was, of course, hesitant to "give advice." That's always
a dangerous path to tread, even if the person really seems to
be asking. More often than not, they are looking for something
that will bring on a "shakedown" in their lives, which
they can then blame on you. Nevertheless, it seemed pretty desperate
and heartfelt a plea, and I responded:
I saw your situation completely when you first wrote to me.
It was very much my own with slight variations and yours has
lasted longer.
What
is the difference?
Everything
you have said, I could have said myself in one way or another.
The same descriptions of the husband, the same descriptions
of the relationships... etc etc etc... What is the difference?
...I
started to READ the clues. And you have the SAME clues I had.
I noticed that my health improved and my mind was clear when
my ex was absent. I noticed that "fortunes" improved when, and
ONLY when, I was in charge of what happened. I noticed that
HE was also declining in health and that was a clue that I was
as "bad" for him as he was for me. And by these small, subtle
clues, put alongside all the "lessons" I was being led through
by C's and my life... I made a decision that went against everything
that had ever been taught to me by my religion, my culture,
my philosophy and so forth.
I
knew that there was no way to do it "easy" and that a clean,
complete break was the only answer for both of us and that can't
be done in the "slow and gradual" way. I knew that he would
want an explanation, and the one I saw that would make the break
the cleanest and fastest was to tell him that I never cared
for him, that I made a big mistake, and everybody was suffering
from my mistake, including him... and it was all MY fault. And
I let him lambaste me and say all the terrible things he wanted
to say, and said 'yes, you are right - I'm a lousy person.'
And I held my ground no matter HOW painful it was.
So,
that is what is different.
I
stopped living in the illusion that I could make anything better
or different than it WAS.
What
is more, I chose to SEE it as it WAS, coldly, clearly, without
emotion.
Then,
I DID something about it.
And
the whole Universe changed.
That
is the power of such as we are. If we only access it. It isn't
easy. It flies in the face of all our human programming and
all the emotional "vectoring" we live under. But the bottom
line is: you cannot be "unequally yoked." If you are, the effect
is that of two mules harnessed ass to ass pulling in opposite
directions - spiritually, karmically, and even literally. Your
life, your environment, your experiences REFLECT the state of
your soul. Poverty, illness, instability, and so on... all
are reflections of what is being done to you spiritually BY
YOUR CHOICES. And your choices are being manipulated
and influenced by early damage which was done for the very purpose
of [making you food.] That's the bottom line.
But
again, what I am saying is something that has to be TESTED.
There is NO PROOF!
I
had no proof, just the small clues - all of which I was clever
enough to explain away for many years; most of which explanations
had to do with the idea that I could do more, I could try this;
I could cut off another arm or open my figurative veins and
give more of my lifeblood to "fix it."
Well,
I finally stopped making excuses. I stopped blaming myself for
anything except that I had made the wrong choice and now I needed
to make a different one - a LIFE changing choice based on clues
that were so subtle that I couldn't even explain them to anyone
at all.
Well,
that isn't true. My friend Sandra ... gave me a gift. She told
me that I must make a list of the clues. I must NEVER forget
them. When I felt weak, when I felt like I wanted to go 'back,"
when I started to forget WHY I was doing what I was doing, I
should take out my list and remember all the horror, all the
pain, all the suffering and that I should remind myself over
and over again until it sank in that all of this was the BIGGEST
part of my marriage and my life. The little "happinesses" or
"good times" were few and far between and never sufficient to
balance the negative.
...
So, I hope this helps. As the C's once told us: If you have
the courage of a lion, you don't have the fate of a mouse.
This
poor woman truly made my heart bleed. And, it seemed that, perhaps,
my words had helped her. She wrote back:
Thank
you. I don't want the fate of the mouse. There is a lion somewhere
in the back of the cave, it has been sleeping for many years.
The
next day she wrote again:
I
woke up the lion this morning, and what you described is in
full process. I don't need to give you a picture. Perhaps the
difference is that we have been together 33 years, and there
is a very strong bond between us. However it is like an umbilical
cord that has to be cut for further growth to happen, and he
cannot see it. For once I am being totally selfish, and my only
pain is to see the pain he is undergoing. Thank you for giving
me the impetus to go through with this.
Her
description of her view of the process told me that she didn't
really "get it." She was still living "in the Myth."
She was already excusing the "difficulty" of the situation
by the length of time together. Then, she described the connection
in nurturing terms as an "umbilical cord," instead of
what it was: a 4th density STS feeding tube. And, finally, she
described her actions as "totally selfish" resulting
in pain from seeing what "he was going through." She
just simply didn't realize that both of them were experiencing
"withdrawal," and that it was purely physical and based
on associations in the amygdala. She didn't get it that, in the
deepest of terms, what she was doing was as much FOR him as it
was for herself. He was as much an addict as she was.
Well,
a couple of days went by and I was inclined to think that she
was not going to "make it," but I was leaving it open
as a possibility. She finally wrote back:
For
36 hours I created hell for myself and everybody around me (my
husband) and within telephone reach. By that time I was so exhausted
I forgot the reason I wanted to leave and went to bed, as did
my husband, and we both slept a long long time. We have reached
a new understanding and to my surprise he respects my courage
and realizes he must take me more seriously than in the past.
He is now being supportive of my goals, and the constant tension
and resentment between us has dissolved.
This
was not a surprise. And, it should not have been a surprise to
her, either. I am sure that she went through a minor version of
this scenario with every fight and argument they had over the
years, all ending in "agreement" to continue the addiction.
And, we also see an example of what I already described: an addiction
to the whole "reward system" of fighting and making
up. People are programmed to suffer because it feels so good when
it's over! It is almost a deliberate creation of "risk"
so that the rush of dopamine can come when the danger has passed.
Now,
the most interesting thing is that it was clearly not apparent
to this woman that her very life and relationships had also programmed
her children to the same behavior, i.e. manipulation and addiction!
The "programs" kicked in BIG TIME:
The
next day I called back my daughter who was sleeping off a drunk
from not being able to bear the thought of her mom and dad separating.
Then I called her brother who likewise had a bad hangover for
the same reason, and was mighty relieved to hear I had changed
my mind. Then I called my other son who was happy he didn't
have to come pick me up with my considerable belongings. Then
I e-mailed several friends to whom I had announced the sad news.
By then I was tired again, but calm.
The
point is that I discovered I am part of a family network , not
just a solitary item responsible only to myself. I had never
looked at it that way. ... perhaps it's a combination of things:
economic (I have literally no money of my own), the logistics
of it all, and last but not least the fact that it tears me
apart to give such pain to so many people. I seem to be divided
into many selves all of which are a part of someone else. My
strongest motive was perhaps the desire to find someone with
whom I would feel more sexually/spiritually compatible. It is
possible to achieve the former with my husband but not both
together. ...Am I chickening out? ...Probably. But then is it
all worth the upheaval? ...My husband now knows I am capable
of what I never seriously threatened to do before, and he greatly
respects my frankness. I was astonished at his reaction. I will
tell you that he was my first husband/mate/whatever in my first
life on this Earth, and we have been together for many many
lifetimes. I also know this is the last one, for we have taught
each other all the lessons each needs to receive. I think my
next life will be a more harmonious one, for in this one I have
lived several lifetimes.
So,
we see an enormous number of rationalizations coming together
here. Will any of them change the situation? Not likely. For the
moment, the "control" is in the hands of my correspondent;
and perhaps this is what she was really looking for: a way to
manipulate the situation herself. Perhaps this was a repeating
dynamic on a lesser scale throughout their lives; I don't know.
And,
in the end, it reminds me of certain remarks from the movie The
Matrix
The
Matrix is everywhere, it is all around us; even now in this
very room. You can see it when you look out your window or when
you turn on your television. You can feel it when you go to
work; when you go to church; when you pay your taxes; it is
the world that has been pulled over your eyes to blind you from
the truth: that your are a slave. Like everyone else, you were
born into bondage; born into a prison that you cannot smell
or taste or touch; a prison for your mind.
...The
Matrix is a system... That system is our enemy.
When
you are inside [the Matrix] you look around; what do you see?
Businessmen, teachers, lawyers, carpenters; the very minds of
the people we are trying to save. But until we do, these people
are still a part of that system and that makes them our enemy.
You
have to understand: most of these people are not ready to be
unplugged; and many of them are so inured, so hopelessly dependent
on the system, that they will fight to protect it.
...We
never free a mind once it's reached a certain age - it's dangerous
- the mind has trouble letting go.
Now,
even though the movie is an allegory that portrays the Matrix
as a computer program, there are many things about this analogy
that can be highly instructive. For example, when Neo is being
introduced to the Matrix, he touches a chair and asks wonderingly,
"This isn't real?" And Morpheus replies:
What
is real? How do you define real? If you are talking about what
you can feel, what you can smell and taste and see; real is simply
electrical signals interpreted by your brain. ...[The Matrix Reality]
is a neural interactive simulation ... a dreamworld created in
order to change a human being into ...
And,
I insert in place of the battery that Morpheus holds up: FOOD.
Let
me quote it one more time: The Matrix is a neural interactive
simulation...
And
it is in this way that we are "programmed" to engage
in damaging behavior via 4th density control systems. If our chemicals
are stimulated while we are "being led down the primrose
path" in any of a number of situations, the brain will "set
a circuit" to repeat this behavior in order to feel the pleasure
chemicals released at the end of the behavior, regardless of the
painful process by which the chemicals are ultimately obtained.
Now,
let's go back to synthetic ligands: drugs, to see if we can glean
any more clues.
When
cocaine is snorted up the nose, it heads straight for the dopamine
re-uptake sites and blocks them. The "feel good sensation"
is not, however, from the drug; but from the fact that dopamine
is flooding your cells, binding with the dopamine receptors like
crazy, unable to be reabsorbed. And the brain only knows one thing:
this feels GREAT! Crack cocaine reportedly produces a more intense
sensation of pleasure than any natural act, including orgasm!
And, take note that it is from the body's OWN chemical that this
pleasure is experienced!
Morphine
and Heroin work in a slightly different way. They mimic endorphins
which trigger the release of dopamine. So, instead of the sensation
occurring because the natural flow of dopamine is not reabsorbed,
it occurs because there is too much dopamine to be absorbed!
But,
there is something very curious about this: it seems that with
repeated use of cocaine, heroin or morphine, the "fake endorphin"
that binds with the opiate receptor and sends a signal into the
cell body to release more dopamine, the body reacts by reducing
the number of receptors! With fewer receptors, the effects of
the drug - as well as the body's normal ability to bind dopamine
that is naturally present - plummets. And, without the normal
flow of dopamine into a normal number of receptors, the brain
experiences "withdrawal" which is interpreted quite
literally as "pain." It is the agony of a mind that
can feel no pleasure at all. Clinicians describe it as:
Abrupt
discontinuation of cocaine, heroin or morphine leads to a state
of dopamine depletion, which can cause the intense depression
and agitation experienced during the crash phase as well as the
subsequent anhedonia, dysphoria, lethargy, somnolence and apathy
that can be present for six to 18 weeks after discontinuation
of cocaine. [Daly
and Salloway, Psychiatric Times, May 1994]
But,
more serious than that is the fact that dopamine plays an important
role in controlling movement, emotion and cognition. Dopamine
dysfunction has been implicated in schizophrenia, mood disorders,
attention-deficit disorder, Tourette's syndrome, substance dependency,
tardive dyskinesia, Parkinson's disease and so on. Of course,
the situation is a lot more complex because at least seven types
of dopamine receptors have been identified.
The
dopamine cells of the hypothalamus project to the anterior pituitary.
In this area, dopamine acts directly to inhibit the release of
prolactin. Prolactin possesses a myriad of effects with the most
noticeable being lactation.
Now,
going back to our "programs" and "body chemicals,"
we begin to see how it is possible that anything that causes more
dopamine to be released into the system will very likely manifest
the same result as cocaine, heroin and morphine: we will go back
to the behavior over and over again because the imprint of the
way that pleasure is to be achieved has been "set" in
the mind of the child.
Now,
I have not been able to find any studies that suggest that the
more dopamine secretion a person experiences from the body's own
chemicals in the "normal" way, that the number of receptors
diminishes. However, the very fact that the "high" of
cocaine is the body's own chemical might suggest that this is
so. This means that each time a person succeeds in some way in
attaining that "feel good" moment - no matter how it
is achieved - the more will be required to experience that same
level of feeling again. This may be why "love states"
so rapidly diminish and turn into battles to produce threat of
loss so that it can be averted and thereby produce the "rush
of dopamine." That is to say: the more that is experienced,
the less it CAN be experienced; so it becomes a physiological/psychological
"carrot on a stick."
But,
even in such situations, the point arrives when the body simply
can no longer meet the demand and nothing works anymore. How soon
this point is reached depends on many factors, and I am sure the
reader can think of any number of situations of their acquaintance
that will demonstrate the great variety of ways these scenarios
can play out.
Another
feel good body chemical is seretonin. The antidepressants, Prozac
and Zoloft block seretonin re-uptake sites causing the brain and
body to be flooded with seretonin. People are happy because seretonin
is lighting up the "do-it-again" center like a Hollywood
Marquee!
In
the early 1980s, clinical investigators discovered a link between
serotonin and eating disorders. ... Richard and Judith Wurtman
(Massachusetts Institute of Technology) had already implicated
serotonin in eating disturbances. They theorized that dietary
starch is converted to sugar, sugar stimulates the pancreas to
release insulin, insulin raises brain levels of the amino acid
tryptophan, tryptophan is a precursor of serotonin, and serotonin
regulates mood, producing a sense of well-being. Therefore, obese
people load up on carbohydrates to elevate mood.
According
to the National Institutes of Health and the Centers for Disease
Control, more than 30% of Americans are 20% or more overweight,
and one third of women and more than one quarter of men are trying
to lose weight at any given time. They have good reason to lose
weight: obesity is severely stigmatized in our society. The health
hazards of being moderately overweight are exaggerated (excess
mortality is not seen until body weight is more than 40% above
tabulated weights on life insurance tables), but it is a definite
social no-no to be fat.
Anorexia
nervosa and bulimia nervosa are psychiatric syndromes whose underlying
pathology has been described as the relentless pursuit of thinness.
The two diseases are separate entities, although there is considerable
overlap; about 50% of anorectics binge and purge. Both diseases
occur primarily in adolescence and young adulthood, they run a
long and protracted course, and they interfere with normal development
(social maturation, separation from family of origin, and career
decisions).
Anorexia has been described in the psychiatric literature for
more than a century, but bulimia has only been recognized as
a clinical entity in the last 16 years. Patients are challenging
and difficult to treat. Indeed, it seems that to be effective,
any treatment must ultimately produce thinness. In other words,
if a bulimic could achieve thinness without having to vomit,
then that patient would be "cured" of bulimia. If an anorectic
could achieve thinness without having to starve, that patient
could be "cured" of starvation.
The
typical patient with anorexia nervosa or bulimia nervosa is
female, young, single, and of middle-to-upper socioeconomic
status and has previously shown a tendency to obesity. Depressive
and obsessional symptoms are common, as are a strong family
history of affective disorder. Depression is sometimes attributed
to the starvation, which can produce the same psychological
profile as that seen in mild to moderate major depression. However,
true major depression (either before or after the emaciation)
is far more prevalent in anorectic patients than in the general
population. Although anorexia and bulimia are more often seen
in females, both disorders also occur in males. Sharp et al.
described the clinical features of 24 men with anorexia nervosa.
Bingeing and vomiting were common (50%, the same as in females).
Also remarkably common were depressed mood, early wakening,
obsessional symptoms, and a family history of affective disorders
and alcohol abuse. Age at onset (18.6 years) and at presentation
(20.2 years) was older than in females. The men were mostly
single and of higher socioeconomic status and had a premorbid
tendency towards obesity. Laxative abuse was less frequent in
males than has been reported in females, and excessive exercising
was more frequent. (Sharp CW et al. Int J Eating Disorders.
1994; 15: 125-134.)
And,
as it turns out, increasing the "seretonin" bath in
the brain by administering a seretonin reuptake inhibitors seems
to help in controlling symptoms of bulimia. Increasing the seretonin
in the brain also seems to produce improvement in depression,
carbohydrate craving, and pathological eating habits. The only
problem with this is that these reuptake inhibitors have been
seriously implicated in both valvular heart problems and primary
pulmonary hypertension.
Prozac
is a seretonin reuptake inhibitor that produces many side effects
which include: nausea, headache, nervousness, insomnia, drowsiness,
diarrhea, weight loss, dizziness, and anxiety. It also causes
a side effect that we need to think about for a moment after learning
what we have about the reduction of dopamine receptors with repeated
use of drugs. You see, one of the side effects of Prozac is an
inability to have an orgasm.
The
street drug "Ecstasy," is the common name for MethyleneDioxyMethAmphetamine,
or MDMA. Ecstasy is a central nervous system stimulant and it
is thought to work by boosting the levels of seretonin and dopamine.
Immediate
effects of ecstasy can include increased feelings of self confidence,
well-being, and feeling close to others; a rise in blood pressure,
body temperature and pulse rate; jaw clenching; teeth grinding;
sweating; dehydration; nausea and anxiety. Higher doses of ecstasy
can produce hallucinations, irrational behavior, vomiting and
convulsions.
Now,
since we already know that using such drugs reduces our dopamine
and possibly our seretonin receptors, it's not surprising that
Ecstasy also produces "tolerance."
Ecstasy is known as 'the love drug' and commonly makes users feel
warm and loving, even towards people they may not know well. Ecstasy
can also heighten sexual desire and intensify the sexual experience,
as well as decreasing inhibition. Lab results with animals have
suggested possibilities of long-term brain damage arising from
the reduction of seretonin and dopamine receptors and the ultimate
failure of the brain to produce seretonin at all!
So,
in a roundabout way, we have come around to the fact that it is
very possible that our addictions to our own chemicals may, ultimately
lead to permanent inability to feel any pleasure at all. And we
all know that, as we age, our ability to be "amused"
by simple things diminishes.
I
am torn between being shocked and amused by the spate of recent
commercials for "sexual stimulants" that promise to
"revive the love nature." I think the funniest one is
promoting a product called "Top Gun." But the problem
it suggests is not very funny. It seems that in our sexually permissive
society, where for the past 20 or 30 years everyone has been encouraged
to "claim their natural right" in terms of more orgasms,
better orgasms, extended, multiple and repeaters, and so on may
be at the root of the present problem with achieving any orgasm
at all for so many people.
The
bottom line seems to be: if it feels good, you will want to do
it again and again and more and better. And, if you do, you will
be less and less able to do it at all; and in the end the imbalances
will lead to more pain and suffering and feelings of inadequacy.
And we know what all that is: Lunch!
Now,
nicotine is a most interesting drug. Nicotine mimics one of the
body's most significant neurotransmitter, acetylcholine. This
is the neurotransmitter most often associated with cognition in
the cerebral cortex. Acetylcholine is the primary carrier of thought
and memory in the brain. It is essential to have appropriate levels
of acetylcholine to have new memories or recall old memories.
Now,
let's go off to the side here for a moment. I cruised the net
for sources on acetylcholine and the results were positively amazing
as you will see from the following excerpts:
Acetyl-L-Carnitine
(ALC) is the acetyl ester of carnitine, the carrier of fatty
acids across Mitochondrial membranes. Like carnitine, ALC is
naturally produced in the body and found in small amounts in
some foods. ...Research in recent years has hoisted ALC from
its somewhat mundane role in energy production to nutritional
cognitive enhancer and neuroprotective agent extraordinaire.
Indeed, taken in its entirety, ALC has become one of the premiere
“anti-aging” compounds under scientific investigation, especially
in relation to brain and nervous system deterioration.
ALC
is found in various concentrations in the brain, and its levels
are significantly reduced with aging.(1) In numerous studies
in animal models, ALC administration has been shown to have
the remarkable ability of improving not only cognitive changes,
but also morphological (structural) and neurochemical changes.
...ALC has varied effects on cholinergic activity, including
promoting the release(2) and synthesis(3) of acetylcholine.
Additionally, ALC promotes high affinity uptake of choline,
which declines significantly with age.(4) While these cholinergic
effects were first described almost a quarter of a century ago,(5)
it now appears that this is only the tip of the ALC iceberg.
[Gissen, VRP's
Nutritional News, March, 1995]
It
turns out that Alzheimer's, a veritable epidemic in our country,
is directly related to low levels of acetylcholine. In Alzheimer's
disease, the neurons that make acetylcholine degenerate, resulting
in memory deficits. In some Alzheimer's patients it can be a 90
per cent reduction! But, does anyone suggest smoking and exercising
the brain as a possible cure?
Nope.
Another
interesting little snippet found in a doctoral dissertation by
Galen
Knight says:
Thyrotropin
is the single most important modulator of thyroid function.
However, several of its effects are mimicked by neurotransmitters,
acetylcholine and catecholamines...
Which
suggests to us that low thyroid function can be partly ameliorated
by nicotine as the Cassiopaeans have already stated in so many
words!
The
next excerpt is the most interesting. It is a from a Bioelectromagnetics
Research Laboratory,paper
first presented at a workshop to discuss possible biological and
health effects of Radio Frequency Electromagnetic waves. The workshop
was held by the Department of Bioengineering at the University
of Washington, Seattle. The paper was later presented to "Mobile
Phones and Health, Symposium," October 25-28, 1998, University
of Vienna, Austria. What they are talking about here is the effects
of cell phone towers and the use of cell phones and pagers, etc:
...We
carried out a series of experiments to investigate the effect
of RFR exposure on neurotransmitters in the brain of the rat.
The main neurotransmitter we investigated was acetylcholine,
a ubiquitous chemical in the brain involved in numerous physiological
and behavioral functions.
We
found that exposure to RFR for 45 min decreased the activity
of acetylcholine in various regions of the brain of the rat,
particularly in the frontal cortex and hippocampus. Further
study showed that the response depends on the duration of exposure.
Shorter exposure time (20 min) actually increased, rather than
decreasing the activity. Different brain areas have different
sensitivities to RFR with respect to cholinergic responses [Lai
et al., 1987b, 1988b, 1989a,b].
In
addition, repeated exposure can lead to some rather long lasting
changes in the system: the number of acetylcholine receptors
increase or decrease after repeated exposure to RFR to 45 min
and 20 min sessions, respectively [Lai et al., 1989a].
Changes
in acetylcholine receptors are generally considered to be a
compensatory response to repeated disturbance of acetylcholine
activity in the brain. Such changes alter the response characteristic
of the nervous system. Other studies have shown that endogenous
opioids are also involved in the effect of RFR on acetylcholine
[Lai et al., 1986b, 1991, 1992b, 1996].
Since
acetylcholine in the frontal cortex and hippocampus is involved
in learning and memory functions, we carried out experiments
to study whether exposure to RFR affects these behavioral functions
in the rat. Two types of memory functions: spatial 'working'
and 'reference' memories were investigated.
Acetylcholine
in the brain, especially in the hippocampus, is known to play
an important role in these behavioral functions. In the first
experiment, 'working' memory (short-term memory) was studied
using the 'radial arm maze'. This test is very easy to understand.
Just imagine you are shopping in a grocery store with a list
of items to buy in your mind. After picking up the items, at
the check out stand, you find that there is one chicken at the
top and another one at the bottom of your shopping cart. You
had forgotten that you had already picked up a chicken at the
beginning of your shopping spree and picked up another one later.
This is a failure in short-term memory and is actually very
common in daily life and generally not considered as being pathological.
A distraction or a lapse in attention can affect short-term
memory.
This
analogy is similar to the task in the radial-arm maze experiment.
The maze consists of a circular center hub with arms radiating
out like the spokes of a wheel. Rats are allowed to pick up
food pellets at the end of each arm of the maze. There are 12
arms in our maze, and each rat in each testing session is allowed
to make 12 arm entries. Reentering an arm is considered to
be a memory deficit. The results of our experiment showed that
after exposure to RFR, rats made significantly more arm re-entries
than unexposed rats [Lai et al., 1994].
This is like finding two chickens, three boxes of table salt,
and two bags of potatoes in your shopping cart.
In
another experiment, we studied the effect of RFR exposure on
'reference' memory (long-term memory) [Wang and Lai, submitted
for publication]. Performance in a water maze was investigated.
In this test, a rat is required to locate a submerged platform
in a circular water pool. It is released into the pool, and
the time taken for it to land on the platform is recorded. Rats
were trained in several sessions to learn the location of the
platform. The learning rate of RFR-exposed rats was slower,
but, after several learning trials, they finally caught up with
the control (unexposed) rats (found the platform as fast). However,
the story did not end here. After the rats had learned to locate
the platform, in a last session, the platform was removed and
rats were released one at a time into the pool. We observed
that unexposed rats, after being released into the pool, would
swim around circling the area where the platform was once located,
whereas RFR-exposed rats showed more random swimming patterns.
To
understand this, let us consider another analogy. If I am going
to sail from the west coast of the United States to Australia.
I can learn to read a map and use instruments to locate my position,
in latitude and longitude, etc. However, there is an apparently
easier way: just keep sailing southwest. But, imagine, if I
sailed and missed Australia. In the first case, if I had sailed
using maps and instruments, I would keep on sailing in the area
that I thought where Australia would be located hoping that
I would see land. On the other hand, if I sailed by the strategy
of keeping going southwest, and missed Australia, I would not
know what to do. Very soon, I would find myself circumnavigating
the globe.
Thus,
it seems that unexposed rats learned to locate the platform
using cues in the environment (like using a map from memory),
whereas RFR-exposed rats used a different strategy (perhaps,
something called 'praxis learning', i.e., learning of a certain
sequence of movements in the environment to reach a certain
location. It is less flexible and does not involve cholinergic
systems in the brain).
Thus,
RFR exposure can completely alter the behavioral strategy of
an animal in finding its way in the environment.
...What
is significant is that the effects persist for sometime after
RFR exposure. If I am reading a book and receive a call from
a mobile phone, it probably will not matter if I cannot remember
what I has just read. However, the consequence would be much
serious, if I am an airplane technician responsible for putting
screws and nuts on airplane parts. A phone call in the middle
of my work can make me forget and miss several screws. Another
adverse scenario of short-term memory deficit is that a person
may overdose himself on medication because he has forgotten
that he has already taken the medicine.
Lastly,
I like to briefly describe the experiments we carried out to
investigate the effects of RFR on DNA in brain cells of the
rat. We [Lai and Singh 1995, 1996; Lai et al., 1997] reported
an increase in DNA single and double strand breaks, two forms
of DNA damage, in brain cells of rats after exposure to RFR.
DNA damages in cells could have an important implication on
health because they are cumulative. Normally, DNA is
capable of repairing itself efficiently. Through a homeostatic
mechanism, cells maintain a delicate balance between spontaneous
and induced DNA damage. DNA damage accumulates if such a balance
is altered. Most cells have considerable ability to repair DNA
strand breaks; for example, some cells can repair as many as
200,000 breaks in one hour. However, nerve cells have a low
capability for DNA repair and DNA breaks could accumulate.
Thus, the effect of RFR on DNA could conceivably be more
significant on nerve cells than on other cell types of the body.
Cumulative
damages in DNA may in turn affect cell functions. DNA damage
that accumulates in cells over a period of time may be the cause
of slow onset diseases, such as cancer. ...Cumulative damage
in DNA in cells also has been shown during aging. Particularly,
cumulative DNA damage in nerve cells of the brain has been associated
with neurodegenerative diseases, such as Alzheimer's, Huntington's,
and Parkinson's diseases.
Since
nerve cells do not divide and are not likely to become cancerous,
more likely consequences of DNA damage in nerve cells are changes
in functions and cell death, which could either lead to or accelerate
the development of neurodegenerative diseases. Double strand
breaks, if not properly repaired, are known to lead to cell
death. Indeed, we have observed an increase in apoptosis (a
form of cell death) in cells exposed to RFR (unpublished
results).
However,
another type of brain cells, the glial cells, can become cancerous,
resulting from DNA damage. This type of response, i.e., genotoxicity
at low and medium cumulative doses and cell death at higher
doses, would lead to an inverted-U response function in
cancer development and may explain recent reports of increase
[Repacholi et al., 1997], decrease [Adey et al., 1996], and
no significant effect [Adey et al., 1997] on cancer rate of
animals exposed to RFR.
Understandably,
it is very difficult to define and judge what constitute low,
medium, and high cumulative doses of RFR exposure, since the
conditions of exposure are so variable and complex in real life
situations.
Interestingly,
RFR-induced increases in single and double strand DNA breaks
in rat brain cells can be blocked by treating the rats with
melatonin ... [Lai and Singh, 1997]. Since it is a potent
free radical scavenger, this data suggest that free radicals
may play a role in the genetic effect of RFR. [Lai and Singh,
1998].
Well,
isn't that just fine and dandy!
What
did the Cassiopaeans have to say about the use of cell phones and
cell-phone towers?
Q:
(L) Can you give me an approximate number of aliens currently
interacting with, or on, or under our planet as a whole?
A: "Aliens?" What constitutes such?
Q: (L) Okay. Well then, non-human beings. Extra- terrestrials,
Ultra-terrestrials, and so forth.
A: These bases have naturalized the inhabitants. Anomalies occur
as much because of where the bases are chosen to be located
as any other factor. Magnetic faults and their inherent portals,
you know!
Q: (L) This [source on the Internet] thinks that there is a
rather limited number of aliens, and that people ought to get
together and resist this threat because our numbers are greater.
Is that, in fact, correct?
A: Not point. The question of the hour is: what is the motive?
Build a house step by step, and when it is finished, you can
move into the neighborhood and out of the motel.
Q: (L) Oh jeez. So, these are a bunch of aliens hanging out
in 'motels' waiting for their house to be built. That does not
sound good.
A: Many of you have recently become "bedazzled" by the "information
superhighway," and its accompanying computer hardware. Gee,
we wonder why?
Q: (L) Well, you told us to network. We have been networking
like crazy, digging up information, reading and comparing. Yes,
there is a ton of garbage out there, but if we don't ask, how
will we know?
A: Point was: who is manipulating thee? Not so much you specifically,
but the others? So many kids and kids-at- heart are thunderstruck
by techno-sensory toys. Those cellular phones, those pagers
and the Christmas toy computers... They are like, so cool!
Q: (L) So what are you implying about these techno toys?
A: Ponder.
Q: (L) Give me a clue.
A: Fuzzy jello-brained kids.
Q: (L) Are you saying that pagers and cell phones, and techno
toys that kids get for Christmas can have effects on them that
turn their brains to jello?
A: In a figurative sense. All this technology represents a Brave
New World. Like Huxley said: Woe is to those who have been led
to eat their brains for lunch.
Q: (L) My kids have pagers. Are pagers, in particular...
A: What do you think comprises the signal content?
Q: (L) I don't know. What does comprise the signal content?
A: Microwaves.
Q: (L) What do these microwaves do to the individual?
A: Contour brain cell structure.
Q: (L) Do they emit a signal continuously, or only when they
are being used?
A: Wave cycle low to high.
Q: (L) Well, that's not good. How close does the pager have
to be to you to have this effect?
A: Four meters. Cell phones too and television and computer
screens can be transmitted through thusly.
Q: (L) When you say 'contouring brain cell structure,' what
would be evidence or results of such effects?
A: Increasingly narrow outlooks and being unable to employ discriminatory
thinking.
Q: (L) Confusion?
A: No. Just lack of depth and breadth to one's mental and psychic
abilities.
Q: (A) Now, about pagers... we were told that pagers emit some
radiation which can be detrimental up to a distance of four
meters. As far as I understand a pager is a passive device,
a receiver. It is not emitting anything. How can a pager be
detrimental?
A: Microwave "bounce effect."
Q: (A) So, they bounce from the receiver... I see.
A: Cell phones too.
Q: (L) Is there any kind of device that we can build or purchase
that can emit a blocking signal?
A: Knowledge protects.
And
it is here and now that we are learning how true that statement
is in just about every sense of the word! So, let's get on with
it.
Work
in the Laboratory
of Neurochemistry at the Barrow Neurological Institute principally
concerns molecules critically involved in such signaling called
nicotinic acetylcholine receptors (nAChR). nAChR act throughout
the brain and body as "molecular switches" to connect nerve
cell circuits involved in essential functions ranging from vision
and memory to the control of heart rate and muscle movement.
Defects
in nAChR or their loss cause diseases such as myasthenia gravis
and epilepsy and can contribute to Alzheimer’s and Parkinson’s
diseases and schizophrenia.
nAChR
also happen to be the principal targets of tobacco nicotine.
...nicotine-like medicines show promise in the treatment of
diseases such as attention deficit/hyperactivity disorder (ADHD)
and Tourette’s syndrome and in alleviation of anxiety, pain,
and depression, suggesting involvement of nAChR in those disorders.
...We
have shown that numbers and function of diverse nAChR subtypes
can be influenced by many biologically active substances, ranging
from steroids to local anesthetics, and by agents acting on
the extracellular matrix, the cytoskeleton, on second messenger
signaling, and at the nucleus. We also have shown that chronic
nicotine exposure induces numerical upregulation of many
diverse nAChR subtypes via a post-transcriptional process that
is dominated by effects on intracellular pools of receptors
or their precursors.
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